Abstract: Objective: To determine the effect of administration of nasal ionized saline solution on nasal maximum inspiratory flow (NMIF), maximum expiratory flow (MEF) and frequency of upper respiratory tract infections (URTI) in asthmatic children. Material and methods: Quasi-experimental study, evaluating the evolution, before and after, of patients with poorly controlled asthma and without rhinitis. During four months of treatment with nasal ionized saline, the NMIF, MEF and the frequency of URTI were evaluated. Statistical analysis: χ2 with Yates correction, Mann-Whitney U, Wilcoxon and Friedman. Results: Eighty asthmatic children aged 8.7 ± 2.1 years were included. NMIF of 58.4 ± 19.3 Lpm at baseline and 104.7 ± 29.2 at four months (p <0.05), baseline MEF was 192.7 ± 58.7 and 222.3 ± 67.0 Lpm at the end of follow-up (p <0.05). URTI frequency decreased progressively, 88.8% in the first month to any case in the fourth month (p <0.05). Conclusions: Ionized nasal saline in asthmatics without a rhinitis appears to improve FIMN, FEM, and ITRS frequency, however, randomized clinical trials are required to demonstrate its effectiveness.

Resumen: Objetivo: Determinar el efecto de administración de solución salina ionizada nasal sobre el flujo inspiratorio máximo nasal (FIMN), flujo espiratorio máximo (FEM) y frecuencia de infecciones de tracto respiratorio superior (ITRS) en niños y adolescentes asmáticos. Material y métodos: Estudio cuasi-experimental, evaluando la evolución antes y después, de pacientes con asma mal controlada, y sin diagnóstico de rinitis. Durante cuatro meses de tratamiento con solución salina ionizada nasal se evaluó el FIMN, FEM y la frecuencia de ITRS. Análisis estadístico: χ2 con corrección de Yates, U de Mann-Whitney, Wilcoxon y Friedman. Resultados: Se incluyeron 80 asmáticos de 8.7 ± 2.1 años. FIMN fue de 58.4 ± 19.3 Lpm en la medición basal y de 104.7 ± 29.2 a los cuatro meses (p < 0.05), FEM basal fue de 192.7 ± 58.7 y de 222.3 ± 67.0 Lpm, al final del seguimiento (p < 0.05). La frecuencia de ITRS disminuyó progresivamente, pasando de 88.8% en el primer mes a ningún caso en el cuarto mes (p < 0.05). Conclusiones: La solución salina nasal ionizada en asmáticos sin diagnóstico de rinitis parece mejorar en FIMN, FEM y la frecuencia ITRS, sin embargo, se requieren de ensayos clínicos aleatorizados para demostrar su verdadera efectividad.

<p>In order to evaluate a set of electrical and optical properties by using time-dependent density functional theory (TD-DFT), at level of theory B3LYP/6-31G(d), the 4N-substituted [1,2,4]-Triazole (TAZ) oligomers and substituted derivatives were studied using cyano, amino, methyl and fluoro functional groups. Additionally, specific properties were theoretically evaluated, namely electronic and geometrical properties, excitation energies, λ_max, and the HOMO-LUMO orbital of the different oligomers TAZ with repeated units of 4 to 20 rings. These properties were extrapolated to polymer by using a second order polynomial fit. The oligomers studied exhibited a high molecular planarity, favoring electronic delocalization. Thus, an increase of the monomeric units in the different TAZ oligomers and their corresponding substituents led to an improvement in these properties, showing the best results for the cyano group. The findings contribute to the design of charge carrier polymeric materials and photoluminescent devices (OLEDs).</p>